5-HT4 antagonist 1

Research use only, not for human use.

5-HT4 antagonist 1 is an antagonist of 5-HT4 (pKi = 9.6).

5-HT4 antagonist 1 is an antagonist of 5-HT4 (pKi = 9.6). (In Vivo):5-HT4 antagonist 1 demonstrates good exposure and prolongs t1/2 in other species with t1/2 of 7, 12, and 21 hours for mice, rats, and mini-pig.

5-HT4 antagonist 1 (compound 6b) is a 5-HT4 receptor antagonist with a pKi of 9.6.

5-HT4 antagonist 1 (compound 6b) demonstrates good exposure and prolongs t1/2 in other species, including the mouse (t1/2 7 h), rat (t1/2 12 h) and mini-pig (t1/2 21 h). In Phase I clinical trial, it is found that 5-HT4 antagonist 1 has good oral bioavailability with a steady state plasma t1/2 of >100 h.

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Endocrinology/Hormones

5-HT Receptor

Non-cleavable

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261766-73-8

480.62

C23H36N4O5S

>98% (HPLC)

In Vitro:?DMSO : 20 mg/mL (41.61 mM)

CN1CCN(CC1)S(=O)(=O)CCCN1CCC(CNC(=O)c2cccc3OCCOc23)CC1

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(-20℃)

With Ice Pack

≥ 2 years